Chemistry Heterocyclic Building Blocks Pyridines 2-chloroisonicotinaldehyde
Ambeed provide 19 derivatives of 2-chloroisonicotinaldehyde.
These compounds have the same murcko framework: 2-chloroisonicotinaldehydeNucleophilic Substitution: The chlorine atom can undergo nucleophilic substitution reactions. For instance, it can be replaced by various nucleophiles like hydroxide ion (OH^-), amines, or thiolates to form corresponding alcohols, amines, or thiols.
Aldol Condensation: 2-Chloroisonicotinaldehyde can undergo aldol condensation reactions with itself or with other carbonyl compounds, leading to the formation of β-hydroxy aldehydes or β-unsaturated aldehydes.
Grignard Reaction: The compound can react with Grignard reagents to form alcohol derivatives. The Grignard reagent would add to the carbonyl group, followed by protonation, resulting in an alcohol.
Reduction: 2-Chloroisonicotinaldehyde can be reduced to the corresponding alcohol using reducing agents such as sodium borohydride or lithium aluminum hydride.
Oxidation: It can be oxidized to the corresponding carboxylic acid using oxidizing agents such as potassium permanganate or chromium trioxide.
Michael Addition: The compound can undergo Michael addition reactions with various nucleophiles, such as enolates or thiols, at the α,β-unsaturated position.
Acylation: 2-Chloroisonicotinaldehyde can undergo acylation reactions with acyl chlorides or acid anhydrides to form ketones.
Vilsmeier-Haack Reaction: It can undergo Vilsmeier-Haack formylation, a reaction that introduces a formyl group (CHO) onto aromatic rings.
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2-Chloroisonicotinaldehyde hydrate(contain dehydrate aldehyde)
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2-chloro-3-methylisonicotinaldehyde
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tert-Butyl (6-chloro-4-formylpyridin-3-yl)carbamate
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2-Chloro-3-(trifluoromethyl)isonicotinaldehyde
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2,6-Dichloro-3-hydroxyisonicotinaldehyde
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tert-Butyl (2-chloro-4-formylpyridin-3-yl)carbamate
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2-Chloro-5-fluoropyridine-4-carbaldehyde