Chemistry Heterocyclic Building Blocks Pyridines 2-chloroisonicotinonitrile
Ambeed provide 7 derivatives of 2-chloroisonicotinonitrile.
These compounds have the same murcko framework: 2-chloroisonicotinonitrileSubstitution Reactions: The chlorine atom can undergo substitution reactions with nucleophiles, such as amines or other nucleophilic reagents, leading to the displacement of the chlorine atom with the nucleophile.
Nucleophilic Addition: The cyano group can undergo nucleophilic addition reactions. For example, it can react with strong nucleophiles such as Grignard reagents or organolithium compounds to form corresponding addition products.
Reduction: The cyano group can be reduced to an amine group under appropriate conditions, such as using reducing agents like lithium aluminum hydride (LiAlH4) or catalytic hydrogenation.
Substitution of the nitrile Group: The nitrile group can undergo substitution reactions to form amides, carboxylic acids, or other derivatives. For instance, it can react with primary amines to form amides.
Metalation: The pyridine ring can undergo metalation reactions with strong bases, leading to the formation of metal complexes.
Condensation Reactions: The compound can undergo condensation reactions, such as the synthesis of heterocyclic compounds via cyclization reactions.
Halogenation: The compound can undergo halogenation reactions under appropriate conditions, leading to the introduction of halogen atoms at various positions on the pyridine ring.
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2-Chloro-3-methylisonicotinonitrile
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2-Chloro-5-(trifluoromethyl)isonicotinonitrile
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2-Chloro-6-(trifluoromethyl)isonicotinonitrile