Chemistry Heterocyclic Building Blocks Pyridines 2-chloropyridin-3-amine
Ambeed provide 11 derivatives of 2-chloropyridin-3-amine.
These compounds have the same murcko framework: 2-chloropyridin-3-amineNucleophilic substitution: The amino group (-NH2) can act as a nucleophile and undergo substitution reactions with electrophiles, such as alkyl halides or acyl chlorides, to form substituted products.
Palladium-catalyzed coupling reactions: The amino group can undergo coupling reactions with aryl or vinyl halides in the presence of a palladium catalyst to form C-N bond formation products.
Reductive amination: The amino group can react with carbonyl compounds (aldehydes or ketones) in the presence of reducing agents (such as sodium cyanoborohydride) to form secondary or tertiary amines.
Diazotization: The amino group can be diazotized using nitrous acid (generated in situ from sodium nitrite and acid) to form a diazonium salt, which can further undergo various coupling reactions to form azo compounds.
Acylation: The amino group can undergo acylation reactions with acyl chlorides or acid anhydrides to form amides.
Reduction: The chloro group can be reduced using reducing agents (such as hydrogen gas over a metal catalyst or lithium aluminum hydride) to form the corresponding amine.
Halogenation: The amino group or the pyridine ring can undergo halogenation reactions with halogenating agents (such as chlorine or bromine) under suitable conditions.
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(5-Amino-6-chloropyridin-3-yl)boronic acid
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1-(3-Amino-2-chloropyridin-4-yl)ethanone