Chemistry Heterocyclic Building Blocks Pyridines 2-chloropyridin-3-ol
Ambeed provide 9 derivatives of 2-chloropyridin-3-ol.
These compounds have the same murcko framework: 2-chloropyridin-3-olSubstitution Reactions: The chlorine atom (Cl) in the compound can undergo substitution reactions with various nucleophiles, such as amines or thiols, to replace the chlorine atom with a different functional group.
Oxidation: The hydroxyl group (OH) can undergo oxidation reactions under appropriate conditions to form either a ketone or a carboxylic acid derivative, depending on the reaction conditions and the oxidizing agent used.
Esterification: The hydroxyl group can react with carboxylic acids or acid chlorides in the presence of an acid catalyst to form esters.
Nucleophilic Addition: The pyridine ring can undergo nucleophilic addition reactions with strong nucleophiles at the C-3 position, leading to the formation of substituted pyridines.
Dehydration: Under certain conditions, the compound can undergo dehydration reactions, leading to the formation of unsaturated compounds.
Reduction: The compound can undergo reduction reactions, where the chlorine atom or the hydroxyl group is reduced to a different functional group.
Acetylation: The compound can undergo acetylation reactions, where the hydroxyl group is acetylated to form an acetate ester.
Framework+−
By Key Group+−
By Parent Nucleus+−
By Functional Group+−
Formula Weight+−
Deals click to sign in and save
Ethyl 6-chloro-5-hydroxynicotinate
click to sign in and save
2-Chloro-5-(trifluoromethyl)pyridin-3-ol