Chemistry Heterocyclic Building Blocks Pyridines 2-chloropyridin-4-amine
Ambeed provide 28 derivatives of 2-chloropyridin-4-amine.
These compounds have the same murcko framework: 2-chloropyridin-4-amineSubstitution Reactions: The chlorine atom can undergo substitution reactions with various nucleophiles. For instance, it can react with a strong base to form a nucleophilic species that can substitute the chlorine atom, leading to the formation of a new compound.
Amidation Reactions: The amino group can undergo amidation reactions with carboxylic acids or acyl chlorides to form amides. This reaction is often catalyzed by coupling reagents or by activating agents such as DCC (dicyclohexylcarbodiimide).
Amination Reactions: The amino group can be further functionalized through amination reactions, where it can react with various electrophiles such as alkyl halides or acyl chlorides to form secondary or tertiary amines.
Reductive Amination: The amino group can undergo reductive amination, a process where it reacts with a carbonyl compound in the presence of a reducing agent such as sodium cyanoborohydride to form an amine.
Cross-Coupling Reactions: The amino group can participate in cross-coupling reactions, such as Suzuki-Miyaura or Heck coupling, where it can be coupled with aryl or vinyl halides under appropriate reaction conditions to form biaryl or vinyl-substituted products.
Heterocycle Formation: The compound can participate in heterocycle formation reactions, where it can react with suitable reagents to form fused or non-fused heterocycles containing a pyridine moiety.
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2-Chloro-5-(trifluoromethyl)pyridin-4-amine
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2-Chloro-5-methylpyridine-3,4-diamine
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Methyl 4-amino-6-chloropyridine-2-carboxylate
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1-(4-Amino-2-chloropyridin-3-yl)ethanone
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2-Chloro-6-(trifluoromethyl)pyridin-4-amine
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6-Chloro-N3-methylpyridine-3,4-diamine
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2-Chloro-5-(trifluoromethoxy)pyridin-4-amine