Chemistry Heterocyclic Building Blocks Pyridines 2-chloropyridine 1-oxide
Ambeed provide 10 derivatives of 2-chloropyridine 1-oxide.
These compounds have the same murcko framework: 2-chloropyridine 1-oxideNucleophilic substitution: The chlorine atom in 2-chloropyridine 1-oxide can be replaced by a nucleophile, such as a hydroxide ion, amine, or thiol, leading to the formation of substituted pyridines.
Electrophilic substitution: The pyridine ring can undergo electrophilic aromatic substitution reactions, where electron-rich reagents or catalysts can substitute the hydrogen atom(s) on the pyridine ring. This can lead to the formation of various substituted pyridines.
Reduction: The nitroso group in 2-chloropyridine 1-oxide can be reduced to an amine group using reducing agents like hydrogen gas in the presence of a catalyst (e.g., Raney nickel), or using metal hydrides such as sodium borohydride or lithium aluminum hydride.
Oxidation: The compound can undergo oxidation reactions, where the nitrogen atom or the carbon atom adjacent to the oxygen atom in the N-oxide group can be oxidized to various oxidation states.
Cyclization: Depending on the reaction conditions and reagents, 2-chloropyridine 1-oxide can participate in cyclization reactions leading to the formation of heterocyclic compounds.
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2-Chloro-3-(trifluoromethyl)pyridine 1-oxide
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2-Chloro-5-(2-ethoxy-2-oxoethoxy)pyridine 1-oxide