Chemistry Heterocyclic Building Blocks Pyrimidines 2-chloropyrimidin-4-amine
Nucleophilic Substitution: The amino group can act as a nucleophile in substitution reactions. For example, it can react with alkyl halides to form substituted amines.
Aromatic Substitution: The chloro group in the pyrimidine ring can undergo nucleophilic aromatic substitution reactions.
Coupling Reactions: The amino group can participate in coupling reactions with suitable electrophiles or catalysts to form C-N bonds.
Reductive Amination: The amino group can participate in reductive amination reactions, where it reacts with a carbonyl compound (aldehyde or ketone) in the presence of a reducing agent to form secondary amines.
Amidation: The amino group can react with acyl chlorides, acid anhydrides, or carboxylic acids to form amide bonds.
Condensation Reactions: The amino group can participate in condensation reactions with carbonyl compounds to form imines or Schiff bases.
Functional Group Transformation: The chloro group can undergo substitution reactions to introduce different functional groups.
Cross-Coupling Reactions: The compound can participate in cross-coupling reactions with suitable reagents or catalysts to form C-C bonds.
Cyclization Reactions: Depending on the reaction conditions and the presence of other functional groups, cyclization reactions may occur to form heterocyclic compounds.
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Ethyl 4-amino-2-chloropyrimidine-5-carboxylate
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Methyl 4-amino-2-chloropyrimidine-5-carboxylate
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2-Chloro-5-(trifluoromethyl)pyrimidin-4-amine
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4-Amino-2-chloropyrimidine-5-carboxylic acid
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(4-Amino-2-chloropyrimidin-5-yl)methanol
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4-Amino-2-chloropyrimidine-5-carbaldehyde
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5-Bromo-2-chloro-6-(trifluoromethyl)pyrimidin-4-amine
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2-Chloro-6-(trifluoromethyl)pyrimidin-4-amine
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Methyl 6-amino-2-chloro-5-methoxypyrimidine-4-carboxylate