Chemistry Heterocyclic Building Blocks Pyridines 2-cyclopropyl-4-phenylquinoline
Ambeed provide 12 derivatives of 2-cyclopropyl-4-phenylquinoline.
These compounds have the same murcko framework: 2-cyclopropyl-4-phenylquinoline.
Aromatic Substitution Reactions: The phenyl group in the molecule can undergo electrophilic aromatic substitution reactions. For example, you can perform Friedel-Crafts acylation or Friedel-Crafts alkylation reactions on the phenyl ring to introduce various substituents.
Nucleophilic Substitution Reactions: If there are suitable leaving groups in the molecule, nucleophilic substitution reactions can occur. For example, if there is a halogen substituent, it can be replaced by a nucleophile (e.g., SN1 or SN2 reactions).
Reduction Reactions: The cyclopropyl ring can undergo ring-opening reactions under certain conditions. For example, it can be reduced to a cyclopropane or opened to form an alkene or other products.
Heterocycle Formation: Quinoline itself is a heterocyclic compound, and depending on the reaction conditions, it can participate in various heterocycle-forming reactions.
Oxidation Reactions: The compound can undergo oxidation reactions if suitable functional groups are present, leading to the formation of various oxidation products.
Base-Catalyzed Reactions: If there are acidic protons in the molecule, it can undergo base-catalyzed reactions, such as deprotonation reactions.
Metal-Catalyzed Reactions: Transition metal catalysts can be used to facilitate various transformations of the compound, including cross-coupling reactions or other metal-catalyzed reactions.
Photochemical Reactions: Some reactions may be initiated or accelerated by exposure to light, leading to photorearrangements or other photochemical transformations.
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Ethyl 2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-carboxylate
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(E)-3-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)acrylonitrile
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3-(Bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline
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(E)-Ethyl 7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-5-hydroxy-3-oxohept-6-enoate
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3-(Chloromethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline
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2-Cyclopropyl-4-(2-fluorophenyl)quinoline-3-carbaldehyde
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3-(Bromomethyl)-2-cyclopropyl-4-phenylquinoline
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2-Cyclopropyl-4-(4-fluorophenyl)quinoline-3-carboxylic acid
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2-Cyclopropyl-4-(4-fluorophenyl)quinoline-3-carbaldehyde
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(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)methanol
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(E)-3-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)acrylaldehyde