Chemistry Heterocyclic Building Blocks Pyridines 2-cyclopropylpyridine
Acylation: 2-Cyclopropylpyridine can undergo acylation reactions with acyl chlorides or anhydrides to form N-acyl-2-cyclopropylpyridinium salts.
Alkylation: It can be alkylated at the nitrogen atom using alkyl halides or alkyl sulfonates, leading to the formation of N-alkyl-2-cyclopropylpyridinium salts.
Dealkylation: N-Alkyl-2-cyclopropylpyridinium salts can undergo dealkylation reactions under appropriate conditions to regenerate 2-cyclopropylpyridine.
Nucleophilic Substitution: The pyridine ring in 2-cyclopropylpyridine can undergo nucleophilic substitution reactions at the C2 or C4 positions when reacted with appropriate nucleophiles.
Reduction: Reduction reactions can reduce the pyridine ring or other functional groups present in 2-cyclopropylpyridine using reducing agents like lithium aluminum hydride (LiAlH4) or hydrogenation with a metal catalyst.
Grignard Reactions: It can react with Grignard reagents to form various products through nucleophilic addition reactions.
Heterocyclization: It can participate in heterocyclization reactions to form other heterocyclic compounds by reacting with appropriate reagents.
Protonation: The nitrogen atom in the pyridine ring can be protonated under acidic conditions, forming a positively charged pyridinium ion.
Esterification: 2-Cyclopropylpyridine can react with carboxylic acids and alcohols to form ester derivatives.
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(6-Cyclopropylpyridin-3-yl)boronic acid
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6-Cyclopropyl-2-methylnicotinonitrile
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2-(Pyridin-2-yl)cyclopropanecarboxylic acid
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1-(Pyridin-2-yl)cyclopropanecarboxylic acid
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1-(5-Fluoropyridin-2-yl)cyclopropanecarboxylic acid
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Methyl 1-(5-cyanopyridin-2-yl)cyclopropane-1-carboxylate
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1-(5-Cyanopyridin-2-yl)cyclopropane-1-carboxylic acid
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1-(5-Bromopyridin-2-yl)cyclopropanecarboxylic acid
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1-(6-Cyclopropylpyridin-3-yl)ethanamine
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1-(5-Bromopyridin-2-yl)cyclopropanecarboxamide
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trans-2-(Pyridin-2-yl)cyclopropanecarboxylic acid