Chemistry Heterocyclic Building Blocks Pyrimidines 2-cyclopropylpyrimidine
Ambeed provide 10 derivatives of 2-cyclopropylpyrimidine.
These compounds have the same murcko framework: 2-cyclopropylpyrimidine.
Nucleophilic Substitution: 2-cyclopropylpyrimidine can undergo nucleophilic substitution reactions at positions where the cyclopropyl group is attached. For example, if you react it with a nucleophile (e.g., a strong base like sodium ethoxide), the cyclopropyl group can be substituted with the nucleophile, leading to the formation of a new compound.
Electrophilic Substitution: Depending on the reaction conditions and the substituents on the pyrimidine ring, electrophilic aromatic substitution reactions can occur. For instance, you can react 2-cyclopropylpyrimidine with electrophiles like bromine or nitration reagents to introduce new substituents onto the pyrimidine ring.
Alkylation and Acylation: 2-cyclopropylpyrimidine can also undergo alkylation and acylation reactions. These reactions can introduce alkyl or acyl groups to the pyrimidine ring, respectively.
Hydrogenation: The cyclopropyl group in 2-cyclopropylpyrimidine can be hydrogenated under suitable conditions, leading to the formation of a saturated cyclopropyl ring.
Ring Opening: Under specific conditions, the cyclopropyl ring may undergo ring-opening reactions, resulting in a compound with an open-chain structure.
Oxidation and Reduction: The compound can undergo oxidation or reduction reactions depending on the reaction conditions and reagents used. For example, you can oxidize the compound to introduce oxygen-containing functional groups or reduce it to remove existing functional groups.
Heterocycle Formation: 2-cyclopropylpyrimidine can participate in reactions that lead to the formation of other heterocyclic compounds when reacted with appropriate reagents.
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6-Amino-2-cyclopropylpyrimidin-4-ol
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Methyl 1-(5-bromopyrimidin-2-yl)cyclopropanecarboxylate
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2-Cyclopropyl-6-hydroxypyrimidine-4-carboxylic acid
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Ethyl 4-chloro-2-cyclopropylpyrimidine-5-carboxylate
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Methyl 6-amino-5-chloro-2-cyclopropylpyrimidine-4-carboxylate
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4-Chloro-2-cyclopropylpyrimidin-5-amine