Chemistry Heterocyclic Building Blocks Pyridines 2-fluoro-4-methylpyridine
Ambeed provide 6 derivatives of 2-fluoro-4-methylpyridine.
These compounds have the same murcko framework: 2-fluoro-4-methylpyridineSubstitution Reactions: The fluorine atom in the 2-position of the pyridine ring can undergo substitution reactions with various nucleophiles, such as amines, alcohols, thiols, or cyanide ions, leading to the formation of different functionalized derivatives of the pyridine.
Nucleophilic Aromatic Substitution (SNAr): The fluorine atom in the 2-position can be substituted by various nucleophiles under appropriate conditions, leading to the formation of new substituted products.
Acylation Reactions: The pyridine nitrogen can undergo acylation reactions with acyl chlorides or acid anhydrides, leading to the formation of N-acyl pyridinium derivatives.
Metalation Reactions: The methyl group in the 4-position can undergo metalation reactions with strong bases, forming organometallic intermediates which can further react with electrophiles.
Oxidation Reactions: Both the methyl group and the pyridine ring can undergo oxidation under appropriate conditions, leading to the formation of various oxidized products.
Reduction Reactions: The fluorine atom or the pyridine ring can undergo reduction reactions under suitable conditions, leading to the formation of reduced products.
Halogenation Reactions: The pyridine ring can undergo halogenation reactions with halogens or their derivatives under appropriate conditions.
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