Chemistry Heterocyclic Building Blocks Pyridines 2-fluoro-5-methoxypyridine
Ambeed provide 4 derivatives of 2-fluoro-5-methoxypyridine.
These compounds have the same murcko framework: 2-fluoro-5-methoxypyridineNucleophilic Substitution: The fluorine atom can be substituted by a nucleophile, such as in SN1 or SN2 reactions, leading to the formation of different substituted pyridines.
Electrophilic Aromatic Substitution: The electron-rich pyridine ring can undergo electrophilic aromatic substitution reactions, where electrophiles add onto the ring. The methoxy group can also participate in activating or directing groups for such reactions.
Metalation: The pyridine ring can be metalated at various positions, depending on the reaction conditions and the reactivity of the metal species involved.
Redox Reactions: The molecule may undergo redox reactions, where the fluorine or the methoxy group can act as either an oxidizing or reducing agent depending on the reaction conditions and the reactants involved.
Cross-Coupling Reactions: The fluorine or the methoxy group can be utilized as handles for cross-coupling reactions with appropriate coupling partners, leading to the formation of biaryl or heteroaryl compounds.
Acylation or Alkylation: The pyridine nitrogen can undergo acylation or alkylation reactions, leading to the introduction of acyl or alkyl groups onto the ring.
Ring Opening Reactions: Under certain conditions, the pyridine ring can undergo ring-opening reactions to form open-chain compounds.
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2-(2-Fluoro-5-methoxypyridin-3-yl)acetic acid