Chemistry Heterocyclic Building Blocks Pyridines 2-fluoro-5-methylpyridine
Ambeed provide 6 derivatives of 2-fluoro-5-methylpyridine.
These compounds have the same murcko framework: 2-fluoro-5-methylpyridineElectrophilic Aromatic Substitution: The fluorine atom can undergo substitution reactions with electrophiles, such as nitration, sulfonation, halogenation, or Friedel-Crafts acylation/alkylation, leading to the formation of substituted products.
Nucleophilic Substitution: The fluorine atom can also undergo nucleophilic substitution reactions, particularly with strong nucleophiles or under basic conditions, resulting in the displacement of the fluorine atom with another nucleophile.
Metalation: The pyridine ring can be metalated with strong bases such as butyllithium or Grignard reagents, leading to the formation of metal complexes or organometallic compounds.
Cross-Coupling Reactions: The methyl group can participate in cross-coupling reactions with suitable reagents or catalysts, leading to the formation of biaryl compounds or other coupled products.
Reductive Reactions: The fluorine atom can be reduced to a variety of functional groups under appropriate conditions, such as hydrogenation or metal-mediated reduction.
Oxidative Reactions: The compound can undergo oxidative transformations, such as oxidation of the methyl group to a carboxylic acid or ketone, or oxidation of the pyridine ring to a pyridine N-oxide.
Heterocycle Formation: The compound can participate in heterocyclization reactions, forming fused or spirocyclic heterocycles through intramolecular cyclization reactions.
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2-Fluoro-5-methylnicotinonitrile