Chemistry Heterocyclic Building Blocks Pyridines 2-fluoro-6-methoxypyridine
Ambeed provide 6 derivatives of 2-fluoro-6-methoxypyridine.
These compounds have the same murcko framework: 2-fluoro-6-methoxypyridineNucleophilic Substitution: The fluorine atom can undergo nucleophilic substitution reactions with suitable nucleophiles, such as strong bases or nucleophilic reagents, to replace the fluorine atom with another functional group.
Electrophilic Substitution: The aromatic ring of 2-fluoro-6-methoxypyridine is susceptible to electrophilic aromatic substitution reactions. Electrophilic aromatic substitution reactions can include halogenation, nitration, sulfonation, or Friedel-Crafts acylation/alkylation.
Grignard Reaction: 2-fluoro-6-methoxypyridine can react with a Grignard reagent to form a new carbon-carbon bond.
Reduction: The functional groups present in 2-fluoro-6-methoxypyridine can undergo reduction reactions to form different compounds.
Oxidation: Conversely, 2-fluoro-6-methoxypyridine can be oxidized to form compounds with different oxidation states.
Metalation Reactions: The pyridine ring can undergo metalation reactions with strong bases or organometallic reagents.
Cross-coupling Reactions: 2-fluoro-6-methoxypyridine can participate in cross-coupling reactions with suitable partners, such as Suzuki coupling, Stille coupling, Heck coupling, etc., to form biaryl or heteroaryl compounds.
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(2-Fluoro-6-methoxypyridin-3-yl)boronic acid