Chemistry Heterocyclic Building Blocks Pyridines 2-fluoro-6-methylpyridine
Ambeed provide 20 derivatives of 2-fluoro-6-methylpyridine.
These compounds have the same murcko framework: 2-fluoro-6-methylpyridineElectrophilic aromatic substitution (EAS): Fluorine and methyl group on the pyridine ring can serve as activating or deactivating groups depending on the reaction conditions, influencing the regioselectivity of substitution reactions such as nitration, sulfonation, halogenation, etc.
Nucleophilic substitution: The fluorine atom can be substituted by a nucleophile under appropriate conditions, yielding products like 6-methylpyridine.
Metalation reactions: The pyridine ring can undergo metalation reactions with strong bases like butyllithium or Grignard reagents, leading to the formation of organometallic intermediates.
Reductive reactions: The fluorine atom can be reduced to a hydrogen atom using reducing agents, such as hydrogen gas over a metal catalyst or dissolving metals like zinc.
Functional group transformations: The functional groups present in 2-fluoro-6-methylpyridine can undergo various transformations like oxidation, reduction, or substitution to yield different compounds.
Cross-coupling reactions: The fluorine atom or the methyl group can participate in cross-coupling reactions with appropriate partners under palladium catalysis, leading to the formation of biaryl compounds or other substituted pyridines.
Heterocyclic chemistry: 2-fluoro-6-methylpyridine can participate in various heterocyclic chemistry reactions, such as cyclization reactions to form fused heterocycles or ring-opening reactions.
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2-Fluoro-6-methylpyridin-3-ylboronic acid
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Potassium trifluoro(2-fluoro-6-methylpyridin-3-yl)borate
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(6-Fluoro-2-methylpyridin-3-yl)boronic acid
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(6-Fluoro-2-methylpyridin-3-yl)methanol