Chemistry
Organic Building Blocks
Fluorinated Building Blocks
2-fluoro-N-methylbenzamide
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —F,—C(O)NHCH3).
Cross-Coupling Reactions: Fluorobenzene can be utilized in cross-coupling reactions, such as Suzuki-Miyaura, Negishi, and Stille reactions. These reactions involve coupling a halogenated aromatic compound with an organometallic reagent, resulting in the formation of new carbon-carbon bonds.
Hydrolysis: Under acidic or basic conditions, N-methylbenzamide can undergo hydrolysis to form N-methylbenzoic acid and methylamine.
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(4-Fluoro-3-(methylcarbamoyl)phenyl)boronic acid
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Methyl 2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoate
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(3-Fluoro-4-(methylcarbamoyl)phenyl)boronic acid
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2-((3-Fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoic acid