Chemistry Heterocyclic Building Blocks Pyrimidines 2-iodopyrimidine
Ambeed provide 8 derivatives of 2-iodopyrimidine.
These compounds have the same murcko framework: 2-iodopyrimidineNucleophilic Substitution: The iodine atom can be replaced by a nucleophile in a substitution reaction. This is often done using a nucleophilic source such as amines, thiols, or organometallic reagents.
Suzuki-Miyaura Coupling: 2-Iodopyrimidine can participate in Suzuki-Miyaura coupling reactions, where it reacts with arylboronic acids or estersin the presence of a palladium catalyst to form biaryl compounds.
Stille Coupling: Similar to Suzuki-Miyaura coupling, 2-iodopyrimidine can undergo Stille coupling reactions with organostannanes.
Heck Reaction: 2-Iodopyrimidine can participate in Heck reactions, coupling with alkenes in the presence of a palladium catalyst.
Arylation: 2-Iodopyrimidine can be used as an arylating agent in reactions with amines or ammonia to introduce an aryl group onto the pyrimidine ring.
Reductive Dehalogenation: The iodine atom can be selectively removed through reductive dehalogenation reactions using reducing agents.
Lithiation: The hydrogen at the C-H bond adjacent to the iodine atom can be lithiated, providing a reactive intermediate for further functionalization.
Halogen-Metal Exchange Reactions: The iodine atom can be replaced with a metal group through halogen-metal exchange reactions.
Catalytic Hydrogenation: The double bond in the pyrimidine ring can be reduced using catalytic hydrogenation.
Negishi Coupling: 2-Iodopyrimidine can participate in Negishi coupling reactions with organozinc reagents.
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