Chemistry Heterocyclic Building Blocks Pyridines 2-methoxy-3-(trifluoromethyl)pyridine
Ambeed provide 6 derivatives of 2-methoxy-3-(trifluoromethyl)pyridine.
These compounds have the same murcko framework: 2-methoxy-3-(trifluoromethyl)pyridineElectrophilic aromatic substitution: The electron-rich pyridine ring can undergo substitution reactions with electrophiles, such as halogens, nitro groups, or acyl groups, at the 2-position, 3-position, or both.
Nucleophilic aromatic substitution: The electron-deficient trifluoromethyl group can undergo substitution reactions with nucleophiles, such as amines or thiols, resulting in substitution at the 3-position of the pyridine ring.
Reduction: The trifluoromethyl group can be reduced to a methyl group, for example, using reagents like lithium aluminum hydride (LiAlH4) or hydrogen gas (H2) over a catalyst.
O-Methylation: The methoxy group can undergo O-methylation reactions, where it is replaced by another alkyl or aryl group through the action of methylating agents such as dimethyl sulfate or methyl iodide.
Oxidation: The pyridine ring can be oxidized, for example, to form a pyridine N-oxide, using oxidizing agents such as hydrogen peroxide (H2O2) or peracids.
Esterification: The methoxy group can undergo esterification reactions with carboxylic acids or acid chlorides to form esters.
Metalation: The pyridine ring can undergo metalation reactions with strong bases or organometallic reagents, leading to the formation of metal complexes.
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2-Methoxy-3-(trifluoromethyl)pyridine
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6-Methoxy-5-(trifluoromethyl)pyridin-3-amine
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[6-Methoxy-5-(trifluoromethyl)pyridin-3-yl]boronic acid
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6-Methoxy-5-(trifluoromethyl)nicotinic acid
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6-Methoxy-5-(trifluoromethyl)nicotinaldehyde