Chemistry Heterocyclic Building Blocks Pyridines 2-methoxy-5-nitropyridine
Ambeed provide 8 derivatives of 2-methoxy-5-nitropyridine.
These compounds have the same murcko framework: 2-methoxy-5-nitropyridineElectrophilic aromatic substitution (EAS): The electron-rich nature of the methoxy group can activate the ring towards electrophilic aromatic substitution reactions. The nitro group, being electron-withdrawing, can further enhance this reactivity. Reactions like nitration, halogenation, sulfonation, etc., can occur at the aromatic ring.
Reduction of the nitro group: The nitro group can be reduced to an amino group (-NH2) using reducing agents like iron and hydrochloric acid (Fe/HCl), tin and hydrochloric acid (Sn/HCl), or other suitable reducing agents.
Oxidation of the methoxy group: The methoxy group can be oxidized to a carbonyl group (-CHO) or a carboxylic acid (-COOH) using suitable oxidizing agents like chromic acid (H2CrO4), potassium permanganate (KMnO4), or other oxidizing reagents.
Substitution reactions at the methoxy group: The methoxy group can undergo substitution reactions, such as ether cleavage or substitution with various electrophiles.
Heterocyclic chemistry: The presence of the pyridine ring in 2-methoxy-5-nitropyridine makes it prone to various reactions typical of heterocyclic compounds, including ring-closure reactions, nucleophilic substitutions, and heterocyclic analogs of other known reactions.
Cross-coupling reactions: The aromatic ring can participate in various cross-coupling reactions such as Suzuki coupling, Heck reaction, Stille reaction, etc., for the synthesis of more complex molecules.
Framework+−
By Key Group+−
By Parent Nucleus+−
By Functional Group+−
Formula Weight+−
click to sign in and save
(2-Methoxy-5-nitropyridin-3-yl)boronic acid