Chemistry
Heterocyclic Building Blocks
Pyridines
2-methoxypyridine
Electrophilic aromatic substitution: 2-methoxypyridine can react with electrophiles such as acyl chlorides or alkyl halides to substitute the methoxy group with the electrophile.
Nucleophilic substitution: The methoxy group in 2-methoxypyridine can be replaced by a nucleophile under suitable conditions, such as with strong nucleophiles like Grignard reagents or organolithium compounds.
Metalation: The pyridine ring in 2-methoxypyridine can be metalated by treatment with strong bases such as butyllithium or lithium diisopropylamide (LDA), leading to the formation of a metal complex.
Oxidation: 2-methoxypyridine can undergo oxidation reactions to form various products, such as pyridine N-oxide, using oxidizing agents like hydrogen peroxide or peracids.
Reduction: The pyridine ring or the methoxy group in 2-methoxypyridine can be reduced under appropriate conditions, such as using reducing agents like lithium aluminum hydride or hydrogen in the presence of a catalyst.
Alkylation or acylation: 2-methoxypyridine can undergo alkylation or acylation reactions at the nitrogen atom or the oxygen atom of the methoxy group, respectively, using suitable alkylating or acylating agents.
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5-Amino-2-methoxypyridine-4-carboxylic Acid
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(4-Chloro-6-methoxypyridin-3-yl)methanol
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5-(Boc-amino)-2-methoxyisonicotinic Acid
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tert-Butyl (6-methoxypyridin-3-yl)carbamate
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DIethyl 2-{[(6-methoxypyridin-3-yl)amino]methylene}malonate
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(S)-3-((tert-Butoxycarbonyl)amino)-3-(6-methoxypyridin-3-yl)propanoic acid
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(S)-2-((tert-Butoxycarbonyl)amino)-3-(6-methoxypyridin-3-yl)propanoic acid
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2-Chloro-1-(6-methoxypyridin-2-yl)ethanone
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2-Methoxy-5-(methoxymethoxy)isonicotinaldehyde
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5-Bromo-3-(difluoromethyl)-2-methoxypyridine
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(S)-2-Amino-2-(6-methoxypyridin-2-yl)ethanol dihydrochloride
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(R)-1-(6-Methoxypyridin-3-yl)propan-1-amine dihydrochloride
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(S)-1-(2-Methoxypyridin-4-yl)ethanamine hydrochloride
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4-Iodo-2-methoxy-5-(trifluoromethyl)pyridine