Chemistry Heterocyclic Building Blocks Pyridines 2-methyl-3-nitropyridine
Ambeed provide 9 derivatives of 2-methyl-3-nitropyridine.
These compounds have the same murcko framework: 2-methyl-3-nitropyridineElectrophilic aromatic substitution: The nitro group in the molecule is electron-withdrawing, making the pyridine ring susceptible to electrophilic aromatic substitution reactions. For instance, it can undergo nitration, halogenation, sulfonation, or Friedel-Crafts acylation/alkylation reactions.
Reduction: The nitro group can be reduced to an amino group (-NH2) under appropriate conditions. Common reducing agents for this transformation include iron and hydrochloric acid (Fe/HCl) or tin and hydrochloric acid (Sn/HCl).
Nucleophilic aromatic substitution: If there are suitable leaving groups on the ring, 2-methyl-3-nitropyridine can undergo nucleophilic aromatic substitution reactions. However, such reactions might be limited due to the nature of the pyridine ring.
Metalation reactions: The pyridine ring can be metalated at the 2-position ortho to the methyl group under certain conditions, leading to the formation of organometallic complexes.
Oxidation reactions: The methyl group can undergo oxidation to form a carboxylic acid or ketone, depending on the reaction conditions and reagents used.
Condensation reactions: It can undergo condensation reactions with suitable reagents to form heterocyclic compounds or derivatives.
Framework+−
By Key Group+−
By Parent Nucleus+−
By Functional Group+−
Formula Weight+−
click to sign in and save
tert-Butyl (6-methyl-5-nitropyridin-2-yl)carbamate
click to sign in and save
N,N-DIethyl-6-methyl-5-nitro-2-pyridinamine