Chemistry Heterocyclic Building Blocks Pyridines 2-methylpyridin-4-amine
Ambeed provide 7 derivatives of 2-methylpyridin-4-amine.
These compounds have the same murcko framework: 2-methylpyridin-4-amineElectrophilic aromatic substitution: The amino group in the pyridine ring can undergo substitution reactions with electrophiles. For example, it can react with acyl chlorides or acid anhydrides in the presence of a Lewis acid catalyst to form amides.
Nucleophilic substitution: The amino group can also participate in nucleophilic substitution reactions. For instance, it can react with alkyl halides to form N-alkylated derivatives.
Oxidation reactions: The nitrogen atom in the pyridine ring can be oxidized under certain conditions, leading to the formation of N-oxides or other oxidized derivatives.
Reduction reactions: The nitrogen atom can also undergo reduction reactions, leading to the formation of N-methyl derivatives or other reduced products.
Metal complexation: The nitrogen atom in the pyridine ring can coordinate with transition metal ions to form metal complexes. This can be useful in catalysis or in the synthesis of coordination compounds.
Arylation reactions: The pyridine ring can undergo arylation reactions, where an aryl group is introduced onto the ring. This can be achieved using appropriate arylating agents or metal-catalyzed processes.
Condensation reactions: The amino group can participate in condensation reactions with carbonyl compounds, such as aldehydes or ketones, to form imines or enamines.
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