Chemistry Heterocyclic Building Blocks Pyrimidines 2-methylpyrimidin-4-amine
Ambeed provide 23 derivatives of 2-methylpyrimidin-4-amine.
These compounds have the same murcko framework: 2-methylpyrimidin-4-amineSubstitution Reactions: The amino group in 2-methylpyrimidin-4-amine can undergo substitution reactions. For example, it can react with electrophiles to form N-substituted derivatives.
Nucleophilic Aromatic Substitution: The pyrimidine ring in the compound is aromatic, and it can undergo nucleophilic aromatic substitution reactions under certain conditions. Nucleophiles can attack the aromatic ring, leading to substitution products.
Acylation and Alkylation: The amino group can undergo acylation and alkylation reactions with acyl halides or alkyl halides, respectively. This can lead to the formation of amides or alkylated amines.
Cyclization Reactions: Depending on the reaction conditions and the presence of suitable functional groups, 2-methylpyrimidin-4-amine may participate in cyclization reactions, forming fused or spirocyclic compounds.
Oxidation Reactions: The amino group can be oxidized to form various oxidation products. The specific products will depend on the oxidizing agent and conditions used.
Condensation Reactions: The amino group can participate in condensation reactions, for example, with carbonyl compounds, leading to the formation of imines or Schiff bases.
Metal Complexation: The amino group may coordinate with metal ions to form metal complexes, especially in the presence of suitable ligands.
Diazoes Coupling: If the compound is diazotized, it can undergo diazo coupling reactions with aromatic amines or phenols to form azo compounds.
Framework+−
By Key Group+−
By Parent Nucleus+−
By Functional Group+−
Formula Weight+−
Deals click to sign in and save
N-((4-Amino-2-methylpyrimidin-5-yl)methyl)acetamide
Deals click to sign in and save
5-Fluoro-2-methylpyrimidin-4-amine
Deals click to sign in and save
4-Amino-6-iodo-2-methylpyrimidine
Deals click to sign in and save
6-Chloro-2-methylpyrimidine-4,5-diamine
Deals click to sign in and save
5-Chloro-2-methylpyrimidin-4-amine
click to sign in and save
(4-Amino-2-methylpyrimidin-5-yl)methanol hydrochloride
click to sign in and save
5-(Bromomethyl)-2-methylpyrimidin-4-amine hydrobromide
click to sign in and save
Ethyl 4-amino-2-methylpyrimidine-5-carboxylate
Deals click to sign in and save
5-Fluoro-2,6-dimethylpyrimidin-4-amine