Chemistry Heterocyclic Building Blocks Imidazoles 2-phenyl-1H-imidazole
Halogenation: You can halogenate the phenyl ring in 2-phenyl-1H-imidazole, typically by using reagents like bromine or chlorine. This reaction involves the substitution of hydrogen atoms with halogen atoms.
N-Alkylation: 2-phenyl-1H-imidazole can undergo N-alkylation reactions where an alkyl group (e.g., methyl, ethyl, etc.) replaces a hydrogen atom on the nitrogen atom of the imidazole ring. This is often achieved using alkyl halides and a base, such as sodium hydride or potassium carbonate.
Acylation: Acylation reactions can introduce acyl groups (e.g., acetyl, benzoyl) onto the nitrogen atom of the imidazole ring. Acylation reactions are commonly carried out using acyl halides (e.g., acetyl chloride) or anhydrides in the presence of a base.
N-Methylation: N-methylation reactions replace the hydrogen atom on the nitrogen atom of the imidazole ring with a methyl group. This can be achieved using reagents like methyl iodide or dimethyl sulfate.
Ring Functionalization: The imidazole ring itself can undergo various reactions like ring opening, ring closure, or other functionalization reactions. These reactions can modify the chemical structure of the imidazole ring.
Nucleophilic Substitution: The nitrogen atom of the imidazole ring can act as a nucleophile in reactions with electrophiles, leading to the substitution of the hydrogen atom with various functional groups.
Cross-coupling reactions: You can use cross-coupling reactions, like Suzuki-Miyaura or Heck reactions, to attach various aryl or alkyl groups to the phenyl ring of 2-phenyl-1H-imidazole.
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(2-Phenyl-1H-imidazole-4,5-diyl)dimethanol
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4-(1H-Imidazol-2-yl)benzoic acid hydrochloride
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Ethyl 2-phenyl-1H-imidazole-5-carboxylate
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2-(2-Phenyl-1H-imidazol-4-yl)ethanamine dihydrochloride
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4-Hydroxymethyl-5-methyl-2-phenylimidazole