Chemistry Heterocyclic Building Blocks Morpholines 2-phenylmorpholine

2-phenylmorpholine

Nucleophilic Substitution: The morpholine nitrogen can act as a nucleophile, and the phenyl ring can undergo electrophilic substitution reactions. For example, you can alkylate or acylate the morpholine nitrogen or introduce various substituents on the phenyl ring. Ring Opening Reactions: The morpholine ring can undergo ring-opening reactions, typically under acidic or basic conditions, to yield different products. This can lead to the formation of primary amines or other functionalized products. Amide Formation: You can react 2-phenylmorpholine with acyl chlorides or anhydrides to form amides. This is a common reaction of amines and can be used for introducing amide groups into the molecule. Oxidation: The phenyl group can be oxidized using various reagents to convert it into a phenolic group. Common oxidizing agents include KMnO4, CrO3, or other suitable reagents. Reduction: The nitrogen in the morpholine ring can be reduced to form secondary amines or other reduced products. Common reducing agents include LiAlH4 or NaBH4. Halogenation: You can halogenate the phenyl ring by reacting 2-phenylmorpholine with halogenating agents like Br2 or Cl2. This can lead to the introduction of halogen substituents on the phenyl ring. N-Oxide Formation: You can oxidize the morpholine nitrogen to form a N-oxide using appropriate oxidizing agents.

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(R)-3-phenylmorpholine (S)-3-phenylmorpholine 2,2-dimethylmorpholine 2,6-dimethylmorpholine 2-(methoxymethyl)morpholine 2-(morpholin-2-yl)acetic acid 2-ethylmorpholine 2-isopropylmorpholine 2-methylmorpholine 2-phenylmorpholine 3-(4-morpholinophenyl)oxazolidin-2-one 3-(methoxymethyl)morpholine 3-ethylmorpholine 3-isopropylmorpholine 3-methylmorpholine 3-phenylmorpholine 4-(2-fluorophenyl)morpholine 4-(3-phenoxypropyl)morpholine 4-(o-tolyl)morpholine 4-(pyrazin-2-yl)morpholine 4-(pyridin-4-yl)morpholine 4-(pyrimidin-2-yl)morpholine 4-benzylmorpholin-3-one 4-morpholinoaniline 4-morpholinobenzaldehyde 4-morpholinobenzoic acid 4-phenylmorpholin-3-one 6,6-dimethylmorpholine-3-carboxylic acid benzyl morpholine-4-carboxylate ethyl morpholine-2-carboxylate methyl 2-(morpholin-3-yl)acetate methyl morpholine-2-carboxylate methyl morpholine-3-carboxylate morpholin-2-ylmethanamine morpholin-2-ylmethanol morpholin-3-ylmethanol morpholine-2-carbonitrile morpholine-2-carboxylic acid morpholine-3-carboxylic acid morpholino(phenyl)methanone tert-butyl (morpholin-2-ylmethyl)carbamate tert-butyl 2-(bromomethyl)morpholine-4-carboxylate tert-butyl morpholine-4-carboxylate

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benzylmorpholine cyanomorpholine dimorpholine dioxaborolane-morpholine diphenylmorpholine ethylmorpholine hydroxyethyl-morpholine hydroxymethylmorpholine isopropylmorpholine methylmorpholine morpholin-hydrochloride morpholin-methanol morpholine-carboxylic acid morpholine-carboxylic-acid morpholine-nitrile morpholinecarboxylate morpholino-methanone morpholinobenzaldehyde morpholinobenzo morpholinobenzoic morpholinobenzonitrile morpholinoethanamine morpholinoethanone morpholinoethoxy morpholinoethyl morpholinomethyl morpholinone morpholinophenyl morpholinopropoxy morpholinopyridine morpholinopyrimidin morpholinosulfonyl oxomorpholine phenylmorpholine pyrazo-morpholine pyridyl-morpholine pyrimidine-morpholine trifluoromethyl-phenyl-morpholine

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