Chemistry Heterocyclic Building Blocks Pyridines 2-propoxypyridine
Ambeed provide 9 derivatives of 2-propoxypyridine.
These compounds have the same murcko framework: 2-propoxypyridineNucleophilic Substitution: The propoxy group (-OCH2CH2CH3) can be substituted by a nucleophile, especially if the pyridine nitrogen atom is activated. For example, reaction with strong nucleophiles like Grignard reagents or organolithium compounds can lead to the replacement of the propoxy group.
Acylation: The pyridine nitrogen can undergo acylation reactions, such as Friedel-Crafts acylation, where an acyl group is introduced onto the nitrogen atom.
Alkylation: Similarly, the pyridine nitrogen can undergo alkylation reactions, where alkyl groups are introduced onto the nitrogen atom.
Oxidation: The pyridine ring can be oxidized under appropriate conditions, for example, with strong oxidizing agents to form pyridine-N-oxide.
Reduction: The pyridine ring can be reduced to piperidine under certain conditions, using reducing agents like hydrogen gas over a metal catalyst.
Ether Cleavage: The ether linkage can be cleaved under acidic or basic conditions to generate the corresponding alcohol and pyridine.
Condensation Reactions: It can undergo condensation reactions with carbonyl compounds, for example, forming pyridine derivatives through a variety of condensation reactions like the Hantzsch synthesis.
Framework+−
By Key Group+−
By Parent Nucleus+−
By Functional Group+−
Formula Weight+−
click to sign in and save
(3-Chloro-2-propoxypyridin-4-yl)boronic acid
click to sign in and save
(5-Methyl-2-propoxypyridin-3-yl)boronic acid