Chemistry Heterocyclic Building Blocks Oxazines 2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one

2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one

Ambeed provide 8 derivatives of 2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one.

These compounds have the same murcko framework: 2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one.

Substitution Reactions: The oxazin-3-one ring can undergo substitution reactions, such as nucleophilic substitution, where a nucleophile can attack the carbonyl group. For example, you can perform nucleophilic acylation to replace the oxygen atom with another nucleophile.
Reduction Reactions: The carbonyl group (C=O) can be reduced to form a hydroxyl group (C-OH) using reducing agents like sodium borohydride or lithium aluminum hydride.
Cyclization Reactions: Depending on the reaction conditions, it's possible to perform intramolecular cyclization reactions to form other heterocyclic compounds.
Condensation Reactions: You can perform condensation reactions to link this compound with other molecules or reagents to create larger compounds with extended conjugated systems.
Oxidation Reactions: Depending on the specific substituents and reaction conditions, oxidation reactions can be applied to transform this compound into other products.
Hydrolysis: Under appropriate conditions, you can perform hydrolysis reactions to cleave the oxazin-3-one ring and produce simpler compounds.
Nucleophilic Addition: Nucleophiles can attack the carbon-carbon double bond in the pyrido ring or the oxazin ring, leading to various addition reactions.

Further Reading:
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Framework+−

2,2-dimethyl-2H-benzo[b][1,4]oxazin-3(4H)-one 2-methyl-2H-benzo[b][1,4]oxazin-3(4H)-one 2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one 3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine 6-amino-2H-benzo[b][1,4]oxazin-3(4H)-one 6-bromo-2H-benzo[b][1,4]oxazin-3(4H)-one 6-bromo-3,4-dihydro-2H-benzo[b][1,4]oxazine 6-chloro-2H-benzo[b][1,4]oxazin-3(4H)-one 6-chloro-3,4-dihydro-2H-benzo[b][1,4]oxazine 7-bromo-3,4-dihydro-2H-benzo[b][1,4]oxazine spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one

By Key Group+−

amino-benzooxazine benzoxazin-one benzoxazine benzoxazine-carboxylate benzoxazine-carboxylic-acid bromo-benzooxazin-one bromo-benzooxazine chloro-benzoxazine dimethyl-pyridooxazin fluoro-dihydro-benzoxazine hydroxy-benzooxazine indenotriazolooxazine indoline-oxazine methy-pyrazolooxazine methyl-benzooxazine nitro-benzooxazin phenoxazine pyrazolooxazine pyridooxazin-one pyridoxazine triazol-oxazine

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Aliphatic Heterocycles Piperidines Spiroes

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Amides Chiral Building Blocks

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