Chemistry Heterocyclic Building Blocks Pyridines 3,5-dichloropyridine
Ambeed provide 16 derivatives of 3,5-dichloropyridine.
These compounds have the same murcko framework: 3,5-dichloropyridineNucleophilic Substitution: The chlorine atoms in 3,5-dichloropyridine can be replaced by nucleophiles. For example, treatment with a strong nucleophile like sodium hydroxide (NaOH) can result in substitution to form 3-hydroxypyridine.
Metalation: 3,5-dichloropyridine can react with strong bases such as butyllithium or sodium amide to undergo metalation at the positions adjacent to the chlorine substituents, leading to the formation of corresponding organometallic compounds.
Cross-Coupling Reactions: It can participate in cross-coupling reactions, such as Suzuki, Heck, or Stille coupling, where one of the chlorine atoms is replaced by an organometallic reagent or another aryl or vinyl group, leading to the formation of biaryl or vinyl-substituted pyridines.
Reduction: The chlorine atoms in 3,5-dichloropyridine can be reduced to generate 3,5-dichloropyridine.
Oxidation: It can undergo oxidation reactions to form various oxidized derivatives of pyridine.
Halogenation: It can participate in further halogenation reactions, adding additional halogen atoms to the pyridine ring.
Cyclization: Under certain conditions, it may undergo cyclization reactions, leading to the formation of fused ring systems or heterocyclic compounds.
Functional Group Transformations: 3,5-dichloropyridine can undergo various functional group transformations, such as acylation, alkylation, or sulfonation, depending on the reaction conditions and reagents used.
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(S)-1-(3,5-Dichloropyridin-4-yl)ethanol
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(3,5-Dichloropyridin-4-yl)methanamine