Chemistry Heterocyclic Building Blocks Pyridines 3,5-difluoropyridine
Ambeed provide 12 derivatives of 3,5-difluoropyridine.
These compounds have the same murcko framework: 3,5-difluoropyridineElectrophilic substitution: The electron-rich nature of the pyridine ring makes it susceptible to electrophilic aromatic substitution reactions. For example, it can undergo nitration, sulfonation, halogenation, and Friedel-Crafts acylation/alkylation reactions.
Nucleophilic substitution: The fluorine atoms can undergo substitution reactions, particularly nucleophilic aromatic substitution. Depending on the reaction conditions and the nature of the nucleophile, substitution can occur at either the 3-position, 5-position, or both.
Metalation reactions: 3,5-difluoropyridine can react with strong bases to undergo metalation, where a metal atom replaces a hydrogen atom on the pyridine ring. Common bases used for metalation include butyllithium and organolithium reagents.
Cross-coupling reactions: 3,5-difluoropyridine can participate in various cross-coupling reactions, such as Suzuki coupling, Stille coupling, and Heck coupling. These reactions involve the coupling of the pyridine ring with other organic substrates in the presence of suitable catalysts.
Redox reactions: The fluorine substituents can influence the redox properties of the molecule, allowing it to participate in various redox reactions.
Functional group transformations: The fluorine substituents can also undergo various functional group transformations, such as reduction, oxidation, and substitution reactions.
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(R)-2-Amino-2-(3,5-difluoropyridin-2-yl)ethanol dihydrochloride