Chemistry Heterocyclic Building Blocks Pyridines 3,5-dimethoxypyridine
Ambeed provide 4 derivatives of 3,5-dimethoxypyridine.
These compounds have the same murcko framework: 3,5-dimethoxypyridineElectrophilic Substitution: The electron-rich pyridine ring of DMOP can undergo electrophilic aromatic substitution reactions with electrophiles, such as nitration, halogenation, sulfonation, and Friedel-Crafts acylation/alkylation.
Nucleophilic Substitution: The methoxy groups in DMOP can be substituted by nucleophiles under appropriate conditions. This can occur through reactions such as Williamson ether synthesis or SNAr (nucleophilic aromatic substitution).
Reduction: DMOP can be reduced to its corresponding dihydro derivative, 3,5-dimethylpyridine, using reducing agents like lithium aluminum hydride (LiAlH4) or catalytic hydrogenation.
Oxidation: DMOP can be oxidized to form its corresponding pyridine N-oxide derivative under suitable oxidative conditions.
Alkylation: The pyridine nitrogen can undergo alkylation reactions with alkyl halides or alkylating agents, leading to N-alkylated products.
Cross-Coupling Reactions: DMOP can participate in cross-coupling reactions, such as Suzuki-Miyaura or Heck coupling, when functionalized at appropriate positions.
Cyclization: DMOP can participate in various cyclization reactions, depending on the reaction conditions and reagents involved, leading to the formation of cyclic compounds.
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