Chemistry Heterocyclic Building Blocks Pyridines 3-(bromomethyl)pyridine
Ambeed provide 18 derivatives of 3-(bromomethyl)pyridine.
These compounds have the same murcko framework: 3-(bromomethyl)pyridineSubstitution Reactions: The bromine atom in the bromomethyl group can undergo substitution reactions with various nucleophiles, such as amines or thiols, to form substituted products.
Cross-Coupling Reactions: 3-(bromomethyl)pyridine can participate in cross-coupling reactions, such as Suzuki, Heck, or Stille reactions, to form carbon-carbon bonds with other organic compounds.
Nucleophilic Aromatic Substitution (SNAr): The pyridine ring in 3-(bromomethyl)pyridine can undergo nucleophilic aromatic substitution reactions, where the bromine atom is replaced by a nucleophile, leading to substituted pyridine derivatives.
Reduction Reactions: The bromomethyl group can be reduced to a methyl group using reducing agents like lithium aluminum hydride (LiAlH4) or hydrogen gas in the presence of a catalyst.
Metalation Reactions: The pyridine ring can undergo metalation reactions with strong bases like butyllithium or Grignard reagents, leading to the formation of organometallic compounds.
Functional Group Transformations: Various functional group transformations, such as oxidation, halogenation, or acylation, can be performed on 3-(bromomethyl)pyridine to introduce or modify functional groups.
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3-(Bromomethyl)-5-(trifluoromethyl)pyridine hydrobromide
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3-(Bromomethyl)-2-(trifluoromethyl)pyridine
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5-(Bromomethyl)-2-methylpyridine hydrobromide
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3-(Bromomethyl)-5-methylpyridine hydrobromide
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5-(Bromomethyl)-2-(trifluoromethyl)pyridine
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3-(Bromomethyl)-4-methylpyridine hydrobromide
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3,5-Bis(bromomethyl)pyridine hydrobromide
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5-(Bromomethyl)pyridin-3-amine hydrobromide
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3-(Bromomethyl)-5-fluoropyridine hydrobromide