Chemistry Heterocyclic Building Blocks Pyridines 3-(difluoromethyl)pyridine
Ambeed provide 5 derivatives of 3-(difluoromethyl)pyridine.
These compounds have the same murcko framework: 3-(difluoromethyl)pyridineNucleophilic Substitution: The fluorine atoms in the difluoromethyl group can be substituted by nucleophiles, such as hydroxide ions or amines, leading to the formation of different substituted pyridine derivatives.
Electrophilic Substitution: The pyridine ring can undergo electrophilic aromatic substitution reactions, where an electrophile replaces a hydrogen atom on the ring. Common electrophiles include nitronium ions, acyl chlorides, or alkyl halides.
Metalation: The pyridine ring can be metalated by strong bases like n-butyllithium or Grignard reagents, forming organometallic complexes.
Oxidation: The compound can be oxidized using oxidizing agents such as potassium permanganate or chromic acid, leading to the formation of various oxidation products.
Reduction: It can be reduced using reducing agents such as lithium aluminum hydride or hydrogen gas with a metal catalyst, leading to the formation of saturated derivatives.
Halogenation: The pyridine ring can undergo halogenation reactions, where one or more hydrogen atoms are replaced by halogen atoms (e.g., chlorine, bromine) under suitable conditions.
Ring-closure Reactions: Depending on the reaction conditions and the presence of functional groups, 3-(difluoromethyl)pyridine can undergo ring-closure reactions to form cyclic compounds.
Condensation Reactions: It can participate in condensation reactions with suitable reagents to form heterocyclic compounds or derivatives.
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tert-Butyl (5-(difluoromethyl)-6-methylpyridin-2-yl)carbamate
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1-(5-(Difluoromethyl)pyridin-3-yl)ethanone