Chemistry Heterocyclic Building Blocks Pyridines 3-(methylsulfonyl)pyridine
Ambeed provide 5 derivatives of 3-(methylsulfonyl)pyridine.
These compounds have the same murcko framework: 3-(methylsulfonyl)pyridineNucleophilic Substitution: The methylsulfonyl group can be substituted by a nucleophile, such as a primary amine or a thiol, leading to the formation of corresponding substitution products.
Electrophilic Substitution: The pyridine ring can undergo electrophilic substitution reactions, where the electron-rich aromatic system reacts with electrophiles, such as acyl halides or nitration reagents.
Reduction: The sulfonyl group can be reduced to a sulfide or further to a thiol group using reducing agents like hydrogen gas over a metal catalyst or metal hydrides.
Oxidation: The methylsulfonyl group can be oxidized to a sulfoxide or further to a sulfone using oxidizing agents like peroxides or peroxyacids.
Metalation: The pyridine ring can undergo metalation reactions with strong bases or organometallic reagents to form metal complexes.
Alkylation or Acylation: The pyridine nitrogen can undergo alkylation or acylation reactions, where an alkyl or acyl group is introduced onto the nitrogen atom.
Heterocyclization: Depending on the reaction conditions and reagents, the compound might undergo heterocyclization reactions to form fused or spirocyclic heterocycles.
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5-(Methylsulfonyl)nicotinonitrile