Chemistry Heterocyclic Building Blocks Piperidines 3-(piperidin-1-yl)pyridine
Ambeed provide 5 derivatives of 3-(piperidin-1-yl)pyridine.
These compounds have the same murcko framework: 3-(piperidin-1-yl)pyridine.
Acylation: 3-(piperidin-1-yl)pyridine can undergo acylation reactions, where an acyl group (RCO-) replaces a hydrogen atom on the piperidine or pyridine ring. Common reagents for acylation reactions include acyl chlorides or anhydrides.
Alkylation: Alkylation reactions involve the introduction of alkyl groups onto the piperidine or pyridine ring. This can be achieved using alkyl halides or alkyl sulfonates in the presence of a suitable base.
Reduction: Reduction reactions can be used to convert any functional groups with double bonds or other reducible groups to their corresponding saturated forms. Common reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4) can be employed.
Halogenation: Halogenation reactions involve the substitution of hydrogen atoms with halogen atoms (chlorine, bromine, etc.) on the piperidine or pyridine ring. This can be accomplished using appropriate halogenating agents.
Oxidation: Oxidation reactions can be used to convert certain functional groups to their oxidized forms. Common oxidizing agents include potassium permanganate (KMnO4) or chromium(VI) reagents.
Ring Opening: The piperidine ring can undergo ring-opening reactions under specific conditions. This can lead to the formation of compounds with open-chain structures.
Substitution Reactions: Depending on the reaction conditions and reagents used, 3-(piperidin-1-yl)pyridine can undergo various substitution reactions, such as nucleophilic substitution, electrophilic substitution, or radical substitution.
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(1-(Pyridin-3-yl)piperidin-4-yl)methanol
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5-Bromo-3-(piperidin-1-yl)pyridin-2-amine
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Ethyl 1-(5-bromopyridin-3-yl)piperidine-4-carboxylate