Chemistry Heterocyclic Building Blocks Piperidines 3-(piperidin-4-yl)pyridine
Ambeed provide 5 derivatives of 3-(piperidin-4-yl)pyridine.
These compounds have the same murcko framework: 3-(piperidin-4-yl)pyridine.
Amine Reactions: The piperidine ring in 3-(piperidin-4-yl)pyridine contains a secondary amine group. It can participate in various amine reactions, such as acylation, alkylation, and reductive amination.
Pyridine Reactions: The pyridine ring in the molecule is aromatic and can undergo electrophilic aromatic substitutions, including nitration, halogenation, and Friedel-Crafts reactions.
Nucleophilic Substitution: Depending on the conditions and the presence of suitable leaving groups, nucleophilic substitutions at different positions on the molecule may occur.
Oxidation/Reduction: Depending on the reaction conditions, the molecule may undergo oxidation or reduction reactions. The piperidine ring, for example, can be oxidized to a piperidinium cation.
Lewis Acid/Base Reactions: The lone pair of electrons on the nitrogen atom in the piperidine ring can act as a Lewis base and interact with Lewis acids.
Heterocyclic Chemistry: Due to the presence of both a piperidine and pyridine ring, this compound may participate in various heterocyclic reactions.
Hydrogenation: The pyridine ring can be hydrogenated to form piperidine derivatives under suitable conditions.
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2-Bromo-5-(piperidin-4-yl)pyridine 2,2,2-trifluoroacetate
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tert-Butyl 4-(6-aminopyridin-3-yl)piperidine-1-carboxylate
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3-(Piperidin-4-yl)pyridine hydrochloride