Chemistry Heterocyclic Building Blocks Pyrrolidines 3-(pyrrolidin-2-yl)pyridine
Ambeed provide 6 derivatives of 3-(pyrrolidin-2-yl)pyridine.
These compounds have the same murcko framework: 3-(pyrrolidin-2-yl)pyridine.
Acylation: You can react 3-(pyrrolidin-2-yl)pyridine with acyl chlorides or anhydrides to introduce acyl groups at the pyridine nitrogen or the pyrrolidine nitrogen.
Alkylation/Arylation: 3-(pyrrolidin-2-yl)pyridine can undergo nucleophilic substitution reactions with alkyl or aryl halides to introduce alkyl or aryl groups.
Reduction: You can reduce the carbonyl group to the corresponding alcohol using reducing agents like NaBH4 or LiAlH4.
Oxidation: You can oxidize the alcohol or other functional groups using suitable oxidizing agents like chromates or Jones reagent.
Ring-Opening Reactions: The pyrrolidine ring can undergo ring-opening reactions under various conditions, leading to the formation of open-chain compounds.
Condensation Reactions: It can participate in condensation reactions, such as the Knoevenagel condensation, to form C-C bonds.
Halogenation: You can halogenate the pyridine ring or the pyrrolidine ring using appropriate halogenating agents.
Cyclization: Depending on reaction conditions, it may undergo intramolecular reactions to form cyclic compounds.
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2-Methyl-5-(pyrrolidin-2-yl)pyridine
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2-Methyl-3-(pyrrolidin-2-yl)pyridine dihydrochloride
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tert-Butyl 2-(6-chloropyridin-3-yl)pyrrolidine-1-carboxylate