Chemistry Heterocyclic Building Blocks Pyridines 3-(tert-butyl)pyridine
Ambeed provide 5 derivatives of 3-(tert-butyl)pyridine.
These compounds have the same murcko framework: 3-(tert-butyl)pyridineNucleophilic Substitution: The tert-butyl group is susceptible to nucleophilic substitution reactions. For instance, it can undergo substitution by a nucleophile at the tert-butyl carbon, leading to the formation of a new compound with the nucleophile attached to the pyridine ring.
Acylation: The pyridine nitrogen can undergo acylation reactions, where an acyl group is attached to the nitrogen atom. This can be achieved using acyl chlorides or acid anhydrides in the presence of a suitable base or catalyst.
Oxidation: Both the pyridine ring and the tert-butyl group can be oxidized under appropriate conditions. Oxidation of the pyridine ring might lead to the formation of pyridine N-oxide derivatives, while oxidation of the tert-butyl group can result in the formation of tert-butyl alcohols or ketones.
Alkylation: The pyridine nitrogen can undergo alkylation reactions, where an alkyl group is attached to the nitrogen atom. This can be achieved using alkyl halides or alkyl sulfonates in the presence of a suitable base.
Ring-closure Reactions: Depending on the reaction conditions and the presence of functional groups, ring-closure reactions might occur leading to the formation of cyclic compounds.
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5-(tert-Butyl)pyridin-3-amine hydrochloride