Chemistry Heterocyclic Building Blocks Pyridines 3-(trifluoromethyl)pyridin-2-ol
Ambeed provide 5 derivatives of 3-(trifluoromethyl)pyridin-2-ol.
These compounds have the same murcko framework: 3-(trifluoromethyl)pyridin-2-olSubstitution Reactions: The hydroxyl group (-OH) in the molecule can undergo substitution reactions, where it is replaced by another functional group. For instance, it can be converted into an alkyl halide through reaction with thionyl chloride or phosphorus tribromide.
Acetylation: The hydroxyl group can be acetylated to form an acetate ester using acetic anhydride or acetyl chloride in the presence of a base.
Aromatic Substitution: The aromatic ring in the molecule can undergo substitution reactions, such as electrophilic aromatic substitution or nucleophilic aromatic substitution, depending on the reaction conditions and reagents used.
Oxidation Reactions: The alcohol group can undergo oxidation to form a ketone or carboxylic acid. Common oxidizing agents like chromic acid or potassium permanganate (KMnO4) can be employed.
Reduction Reactions: The carbonyl group in the molecule can be reduced to an alcohol or further to a hydrocarbon. Various reducing agents such as sodium borohydride (NaBH4) or lithium aluminum hydride (LiAlH4) can be utilized.
Grignard Reaction: The compound can undergo reaction with a Grignard reagent, resulting in the formation of a new carbon-carbon bond.
Esterification: The hydroxyl group can react with carboxylic acids to form esters.
Ether Formation: The alcohol group can react with an alkyl halide or alkoxide ion to form ethers.
Protonation: The nitrogen atom in the pyridine ring can be protonated under acidic conditions.
Nucleophilic Addition: The pyridone ring can undergo nucleophilic addition reactions at the carbonyl group.
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5-Chloro-3-(trifluoromethyl)pyridin-2-ol
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Methyl 6-hydroxy-5-(trifluoromethyl)picolinate