Chemistry Organic Building Blocks Bromides 3-bromo-2-fluorobenzoic acid
Ambeed provide 9 derivatives of 3-bromo-2-fluorobenzoic acid.
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—F,—COOH).
Sonogashira Coupling: Bromobenzene can undergo coupling reactions with terminal alkynes using a palladium catalyst, leading to the formation of substituted alkynes.
Fluorine Substitution: Fluorobenzene can undergo further substitution reactions to replace the fluorine atom with other functional groups. This can be achieved through nucleophilic aromatic substitution reactions. The electron-withdrawing nature of fluorine can affect the regioselectivity and reactivity of such substitutions.
Neutralization Reaction with Bases: Benzoic acid can react with bases to form water-soluble salts called benzoates. The reaction is a typical acid-base neutralization reaction, where the hydrogen ion from the carboxylic acid group is replaced by a metal cation or another positively charged organic group.
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3-Bromo-2-fluoro-6-methyl-benzoic acid