Chemistry
Organic Building Blocks
Bromides
3-bromo-2-fluorobenzonitrile
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—F,—C≡N).
Electrophilic Aromatic Substitution (EAS): Bromobenzene can react with electrophiles in substitution reactions, such as nitration, sulfonation, halogenation, and Friedel-Crafts acylation/alkylation.
Cross-Coupling Reactions: Fluorobenzene can be utilized in cross-coupling reactions, such as Suzuki-Miyaura, Negishi, and Stille reactions. These reactions involve coupling a halogenated aromatic compound with an organometallic reagent, resulting in the formation of new carbon-carbon bonds.
Cyanohydrin Formation: Benzonitrile can react with carbonyl compounds in the presence of hydrogen cyanide (HCN) to form cyanohydrin compounds.
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3-Bromo-2-fluoro-5-methylbenzonitrile