Chemistry Heterocyclic Building Blocks Pyridines 3-bromo-5-fluoropyridine
Substitution reactions: The bromine atom can be replaced by various nucleophiles, such as amines, thiols, or organometallic reagents, leading to the formation of substituted pyridines.
Cross-coupling reactions: 3-bromo-5-fluoropyridine can undergo cross-coupling reactions with organometallic reagents (e.g., Grignard reagents, organozinc reagents, or organoboranes) in the presence of palladium or nickel catalysts to form biaryl compounds.
Metalation reactions: The bromine atom can be selectively metalated with strong bases like butyllithium or LDA (lithium diisopropylamide) to form organolithium intermediates, which can then undergo further reactions with electrophiles.
Reductive reactions: The bromine atom can be replaced by hydrogen via catalytic hydrogenation reactions using appropriate catalysts like palladium on carbon or Raney nickel.
Functional group transformations: Various functional groups (e.g., amino, hydroxyl, cyano) can be introduced at the 3-position or 5-position of the pyridine ring through suitable synthetic transformations such as nucleophilic substitution, oxidation, or reduction reactions.
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5-Bromo-3-fluoro-2-(trifluoromethoxy)pyridine
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5-Bromo-3-fluoro-2-(methylsulfonyl)pyridine
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5-Bromo-3-fluoro-2-(trifluoromethyl)pyridine
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2-(5-Bromo-3-fluoropyridin-2-yl)acetonitrile