Chemistry Heterocyclic Building Blocks Pyridines 3-bromopicolinic acid
Ambeed provide 9 derivatives of 3-bromopicolinic acid.
These compounds have the same murcko framework: 3-bromopicolinic acidSubstitution Reactions: The bromine atom can be substituted by various nucleophiles under appropriate conditions, such as amines, thiols, or hydroxide ions. This can lead to the formation of new functionalized derivatives.
Esterification: The carboxylic acid group in 3-bromopicolinic acid can undergo esterification with alcohols in the presence of an acid catalyst, yielding the corresponding ester.
Amide Formation: Reaction with amines can yield amide derivatives through amide bond formation.
Decarboxylation: Under certain conditions, carboxylic acids can undergo decarboxylation, yielding carbon dioxide and a substituted organic compound.
Oxidation/Reduction Reactions: Depending on reaction conditions, 3-bromopicolinic acid can undergo oxidation or reduction reactions, leading to the formation of different oxidation states of the nitrogen-containing heterocycle.
Coupling Reactions: 3-Bromopicolinic acid can participate in coupling reactions with other aromatic compounds or heterocycles under appropriate conditions, forming biaryl or heterobiaryl compounds.
Grignard Reaction: The bromine atom can be replaced by a Grignard reagent, leading to the formation of a substituted pyridine derivative.
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3-Bromo-6-chloropyridine-2-carboxylic acid
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3-Bromo-5-(trifluoromethyl)picolinic acid