Chemistry Heterocyclic Building Blocks Pyridines 3-bromopicolinonitrile
Ambeed provide 13 derivatives of 3-bromopicolinonitrile.
These compounds have the same murcko framework: 3-bromopicolinonitrileSubstitution Reactions: The bromine atom in the molecule can undergo substitution reactions, such as nucleophilic substitution or electrophilic substitution, depending on the reaction conditions and the reactants involved. For example, it can undergo nucleophilic substitution with a strong nucleophile to replace the bromine atom with another substituent.
Cross-Coupling Reactions: 3-Bromopicolinonitrile can participate in cross-coupling reactions, such as Suzuki coupling or Stille coupling, where it reacts with another organic compound containing suitable functional groups under catalytic conditions to form a new carbon-carbon bond.
Hydrogenation: Under appropriate conditions, the nitrile group (-CN) in the molecule can be reduced to an amine group (-NH2) through hydrogenation reactions, typically using a metal catalyst such as palladium or platinum.
Nucleophilic Addition: The cyano group (-CN) can undergo nucleophilic addition reactions with suitable nucleophiles to form corresponding addition products.
Halogenation: The pyridine ring can undergo halogenation reactions, introducing additional halogen atoms onto the ring under appropriate conditions.
Oxidation/Reduction: Depending on the reaction conditions, 3-bromopicolinonitrile can undergo oxidation or reduction reactions, leading to the formation of oxidized or reduced products, respectively.
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3-Bromo-5-(trifluoromethyl)picolinonitrile
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3-Bromo-6-(trifluoromethyl)picolinonitrile