Chemistry Heterocyclic Building Blocks Pyridines 3-bromopyridin-2-amine
Ambeed provide 30 derivatives of 3-bromopyridin-2-amine.
These compounds have the same murcko framework: 3-bromopyridin-2-amineSubstitution Reactions: The bromine atom can undergo substitution reactions, where it is replaced by other functional groups or nucleophiles. For example, nucleophilic substitution reactions with various nucleophiles such as amines, thiols, or cyanide can occur to yield corresponding substituted products.
Coupling Reactions: The amine group can participate in coupling reactions with other functional groups. For instance, it can undergo cross-coupling reactions with aryl or vinyl halides in the presence of appropriate catalysts to form biaryl or bivinyl compounds.
Reductive Amination: The amine group can react with carbonyl compounds under reductive conditions to form secondary or tertiary amines. This reaction is particularly useful for the synthesis of substituted amines.
N-Heterocyclic Chemistry: Being a pyridine derivative, 3-bromopyridin-2-amine can participate in various heterocyclic chemistry reactions. It can undergo cyclization reactions with appropriate reagents to form fused heterocycles or other complex structures.
Metalation Reactions: The pyridine ring can be metalated under suitable conditions, leading to the formation of organometallic intermediates. These intermediates can further participate in various coupling or substitution reactions.
Functional Group Transformations: The amine and bromine functional groups can undergo various transformations, such as oxidation, reduction, acylation, alkylation, or arylation, leading to the synthesis of diverse chemical compounds.
Protecting Group Chemistry: The amine or bromine functionalities may require protection in certain synthetic routes to avoid unwanted reactions. Protection and subsequent deprotection strategies can be employed to control the selectivity and outcome of reactions.
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6-Amino-5-bromopyridine-3-sulfonamide
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(6-Amino-5-bromopyridin-3-yl)methanol
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Methyl 2-amino-3,5-dibromoisonicotinate
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3-Bromo-5-(trifluoromethyl)pyridin-2-amine
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3-Bromo-6-(trifluoromethyl)pyridin-2-amine
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3,5-Dibromo-4-(trifluoromethyl)pyridin-2-amine