Chemistry Heterocyclic Building Blocks Pyridines 3-chloro-2-methylpyridine
Ambeed provide 4 derivatives of 3-chloro-2-methylpyridine.
These compounds have the same murcko framework: 3-chloro-2-methylpyridineNucleophilic substitution: The chlorine atom in the 3-position of the pyridine ring can undergo substitution reactions with nucleophiles, such as amines or alkoxides, to form substituted products.
Metalation: The nitrogen atom in the pyridine ring can be metalated with strong bases, such as butyllithium or sodium amide, to form metalated intermediates. These intermediates can then undergo further reactions, such as nucleophilic addition or substitution.
Cross-coupling reactions: The 2-methyl group can serve as a site for cross-coupling reactions, such as Suzuki-Miyaura or Stille coupling, to introduce various functional groups onto the pyridine ring.
Oxidation: The methyl group can undergo oxidation to form a carboxylic acid or ketone derivative, depending on the conditions used.
Reduction: The pyridine ring can be reduced using reducing agents like lithium aluminum hydride or hydrogen in the presence of a catalyst to form piperidine derivatives.
Halogenation: The pyridine ring can undergo halogenation reactions, such as bromination or iodination, under appropriate conditions.
Framework+−
By Key Group+−
By Parent Nucleus+−
By Functional Group+−
Formula Weight+−