Chemistry Heterocyclic Building Blocks Pyridines 3-chloro-5-fluoropyridine
Ambeed provide 10 derivatives of 3-chloro-5-fluoropyridine.
These compounds have the same murcko framework: 3-chloro-5-fluoropyridineNucleophilic substitution: The chlorine or fluorine atom can be substituted by a nucleophile, such as in SN1 or SN2 reactions.
Electrophilic substitution: The pyridine ring can undergo electrophilic aromatic substitution reactions, where an electrophile replaces one of the hydrogen atoms on the ring.
Metalation: The pyridine ring can be metalated by treatment with a strong base and a metalating agent, leading to the formation of metal complexes.
Cross-coupling reactions: 3-chloro-5-fluoropyridine can participate in cross-coupling reactions with various organometallic reagents, such as Grignard reagents or organozinc reagents, to form biaryl compounds.
Reduction: The halogen atoms can be reduced to hydrogen atoms, typically using reducing agents such as lithium aluminum hydride or palladium-catalyzed hydrogenation.
Oxidation: The compound can undergo oxidation reactions, such as oxidation of the carbon-halogen bond to form carbonyl compounds.
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2-(5-Chloro-3-fluoropyridin-2-yl)acetonitrile
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1-(5-Chloro-3-fluoropyridin-2-yl)ethanone
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2-Chloro-1-(5-chloro-3-fluoropyridin-2-yl)ethanone
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1-(5-Chloro-3-fluoropyridin-2-yl)ethanol