Chemistry Heterocyclic Building Blocks Pyridines 3-chloropicolinic acid
Ambeed provide 9 derivatives of 3-chloropicolinic acid.
These compounds have the same murcko framework: 3-chloropicolinic acidSubstitution Reactions: The chlorine atom on the pyridine ring can undergo substitution reactions with various nucleophiles, such as hydroxide ions (OH⁻), amines, or other nucleophilic reagents. This can lead to the formation of substituted pyridine derivatives.
Esterification: The carboxylic acid functional group can undergo esterification reactions with alcohols in the presence of an acid catalyst. This results in the formation of esters.
Acid-Base Reactions: 3-Chloropicolinic acid can undergo acid-base reactions with strong bases to form salts. For example, reaction with sodium hydroxide (NaOH) would yield the sodium salt of the carboxylic acid.
Oxidation: Under appropriate conditions, 3-chloropicolinic acid can be oxidized to yield various oxidation products. The chlorine atom can be oxidized to a more oxidized state, and the carboxylic acid group can also undergo oxidation.
Reduction: Conversely, 3-chloropicolinic acid can be reduced under appropriate conditions, leading to the reduction of the functional groups present in the molecule.
Condensation Reactions: It can participate in condensation reactions, such as the formation of amides or imines, particularly under appropriate conditions with suitable reactants.
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3-Chloro-5-methoxypicolinic acid
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3-Chloro-5-(trifluoromethyl)picolinic acid
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3-Chloro-4-(difluoromethoxy)picolinic acid