Chemistry Heterocyclic Building Blocks Pyridines 3-chloropyridin-2-ol
Ambeed provide 10 derivatives of 3-chloropyridin-2-ol.
These compounds have the same murcko framework: 3-chloropyridin-2-olSubstitution Reactions: The chlorine atom (-Cl) can undergo substitution reactions with various nucleophiles, such as hydroxide ions or primary amines, to form corresponding substituted products.
Esterification: The hydroxyl group (-OH) can react with carboxylic acids and acyl chlorides to form esters. This reaction typically requires the presence of a catalyst such as acid or base.
Ether Formation: The hydroxyl group can undergo etherification reactions with alkyl halides to form ethers. This reaction is often catalyzed by an acid, such as sulfuric acid or hydrochloric acid.
Oxidation Reactions: The hydroxyl group can undergo oxidation reactions to form ketones or carboxylic acids, depending on the reaction conditions and reagents used.
Ring Closure Reactions: The compound can undergo intramolecular cyclization reactions under suitable conditions, leading to the formation of cyclic compounds.
Metal Complexation: Both the chlorine atom and the hydroxyl group can coordinate with metal ions to form metal complexes. This can be utilized in various chemical transformations and catalytic processes.
Reduction Reactions: Both the chlorine atom and the hydroxyl group can undergo reduction reactions under appropriate conditions to form corresponding reduced products.
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Methyl 3,5-dichloro-6-hydroxypicolinate
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3,5-Dichloro-6-hydroxypicolinic acid