Chemistry Heterocyclic Building Blocks Pyridines 3-ethynylpyridine
Ambeed provide 22 derivatives of 3-ethynylpyridine.
These compounds have the same murcko framework: 3-ethynylpyridineSonogashira Coupling: 3-Ethynylpyridine can undergo Sonogashira coupling reaction with aryl or vinyl halides in the presence of a palladium catalyst and a base to form substituted alkynylpyridines.
Hydrogenation: The triple bond in 3-ethynylpyridine can be selectively hydrogenated to form 3-vinylpyridine using a suitable hydrogenation catalyst (e.g., palladium on carbon) under mild conditions.
Halogenation: The triple bond can undergo halogenation reactions such as addition of bromine or chlorine to yield 3-bromo- or 3-chloroethynylpyridine derivatives.
Nucleophilic Substitution: The ethynyl group can be substituted by various nucleophiles such as alkoxides, amines, or thiolates, leading to the formation of substituted alkynylpyridines.
Cross-Coupling Reactions: 3-Ethynylpyridine can participate in various cross-coupling reactions with suitable partners (e.g., Suzuki-Miyaura, Heck, or Negishi reactions) to introduce diverse functional groups onto the pyridine ring.
Cyclization Reactions: Under certain conditions, 3-Ethynylpyridine can undergo intramolecular cyclization reactions to form cyclic compounds, depending on the reaction conditions and the nature of the substituents present.
Oxidation: The ethynyl group can be oxidized to the corresponding carboxylic acid or ketone under appropriate conditions, providing access to different functionalized derivatives of pyridine.
Framework+−
By Key Group+−
By Parent Nucleus+−
By Functional Group+−
Formula Weight+−
click to sign in and save
tert-Butyl (5-ethynylpyridin-3-yl)carbamate