Chemistry Heterocyclic Building Blocks Pyridines 3-fluoro-2-methoxypyridine
Ambeed provide 14 derivatives of 3-fluoro-2-methoxypyridine.
These compounds have the same murcko framework: 3-fluoro-2-methoxypyridineNucleophilic Substitution: The fluorine atom can be substituted by a nucleophile under appropriate conditions, leading to the formation of a new compound with different substituents.
Electrophilic Substitution: The pyridine ring can undergo electrophilic aromatic substitution reactions, where an electrophile substitutes for one of the hydrogen atoms on the ring.
Cross-Coupling Reactions: The fluorine atom can participate in cross-coupling reactions with suitable reagents, such as pyridine catalysts, leading to the formation of biaryl compounds or other coupled products.
Reductive Reactions: The methoxy group can be reduced to a methyl group under certain conditions, such as with metal catalysts like pyridines on carbon and hydrogen gas.
Oxidative Reactions: The compound can undergo oxidation reactions under appropriate conditions, leading to the formation of oxidation products.
Alkylation/Acylation Reactions: The pyridine nitrogen atom can undergo alkylation or acylation reactions with suitable alkylating or acylating agents, respectively.
Heterocyclic Synthesis: It can participate in heterocyclic synthesis reactions, where it may undergo cyclization reactions to form new heterocyclic compounds.
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3-Amino-5-fluoro-6-methoxypyridine
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1-(5-Fluoro-6-methoxypyridin-3-yl)ethanone
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(5-Fluoro-6-methoxypyridin-3-yl)boronic acid
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(3-Fluoro-2-methoxypyridin-4-yl)boronic acid